Royal Caribbean offers some of the most immersive and diverse Mediterranean cruise itineraries in the world. Whether you're dreaming of Italian coastlines, Greek island sunsets, or Spanish architecture, RC ships deliver a perfect blend of culture, history, adventure, and luxury. The Mediterranean region is rich with world-famous destinations, and Royal Caribbean builds its itineraries to help travelers explore both iconic hotspots and lesser-known gems across Southern Europe.
The Mediterranean is typically divided into two main regions: the Eastern Med and the Western Med. The Eastern region includes Greece, Turkey, Croatia, Cyprus, and surrounding areas. The Western region focuses on Italy, France, Spain, Malta, and Monaco. Royal Caribbean sails to both regions depending on the season, offering everything from 5-night getaways to 12-night immersive vacations.
Below, you’ll find a detailed deep-dive into the itineraries, ports, ships, sailing styles, and standout experiences that Royal Caribbean offers across the Mediterranean. This guide also explains how to choose the best itinerary for your travel style—whether you're a beach lover, history fan, foodie, or adventure seeker.
Royal Caribbean offers a wide range of Mediterranean cruise itineraries–some focus on Italy, others highlight the Greek Isles, while many combine multiple countries into a single seamless journey. To help you compare them easily, this section explains the most sought-after Mediterranean routes.
Western Mediterranean cruises are among RC’s most popular because they allow travelers to experience vibrant cultures, historic ports, and iconic landmarks all in one sailing. These itineraries typically begin in cities such as Rome, Barcelona, Marseille, or Venice’s nearby port cities.
Italy is one of the most frequently visited countries on Royal Caribbean Mediterranean cruises. Itineraries often include stops such as:
Naples or Capri, famous for Mount Vesuvius and the Amalfi Coast
Rome (Civitavecchia), for Colosseum tours and Vatican visits
Florence/Pisa (La Spezia or Livorno)
These ports are rich with art, history, and signature cuisine that travelers never forget.
Many RC cruises add French Rivieras such as Marseille and Cannes to their schedule. These ports offer:
Picturesque villages along the coast
Mediterranean beaches
Shopping and café culture
Day trips to Monaco or Nice
Royal Caribbean blends coastal relaxation with chic European sophistication.
Spain is a Western Mediterranean highlight, especially when exploring:
Barcelona
Valencia
Palma de Mallorca
Here, travelers enjoy everything from ancient cathedrals to lively beachfront areas.
Eastern Mediterranean cruises are perfect for travelers seeking cultural depth, clear waters, and ancient history. These itineraries commonly include Greece, Croatia, and Turkey.
Royal Caribbean’s Greek itineraries often include:
Santorini
Mykonos
Rhodes
Crete
Athens (Piraeus)
These islands are known for breathtaking views, classic architecture, and delicious Mediterranean cuisine.
Turkey ports such as Kusadasi open the door to historic wonders like Ephesus, while Croatia introduces fascinating medieval towns such as Dubrovnik and Split.
These itineraries are perfect for travelers seeking a balanced mix. Many RC itineraries combine:
Italy + Greece
Italy + Spain
Italy + France + Greece
Western + Eastern Mediterranean routes
Mediterranean + Adriatic Sea combinations
Combination itineraries offer the most variety and are popular for longer vacations.
Royal Caribbean deploys several of its most popular ships to Europe each summer. Some offer larger-scale experiences with endless entertainment, while others provide a more intimate style suited for Mediterranean ports.
These ships are among the world's largest, offering:
Neighborhood-style onboard environments
AquaTheater shows
Central Park and Boardwalk areas
Multiple dining venues
Their Mediterranean routes often include:
Spain
France
Italy
Some occasional Greek itineraries
Although Oasis-class ships may not access smaller ports due to size, they deliver world-class entertainment and comfort.
Known for innovation, these ships are perfect for travelers seeking:
North Star panoramic pod
Skydiving simulators
High-tech entertainment
Quantum-class ships serve both Western and Eastern Mediterranean routes and sometimes reposition between Europe and Asia.
These ships are smaller and can access many ports that mega-ships cannot. They offer:
Panoramic viewing areas
A more classic cruising experience
Itineraries that include ports like Croatia and the Greek Isles
They’re ideal for travelers who want intimate, scenery-focused experiences.
The Mediterranean region is full of diverse, historic, and scenic ports. Here’s a breakdown of the cities most commonly visited on RC cruises.
Italy’s ports offer a mix of culture, history, and cuisine.
Rome is often used as a departure port and includes attractions such as:
The Colosseum
Trevi Fountain
Vatican City
Known for the Amalfi Coast, Pompeii, and world-famous pizza.
Ideal for art lovers and travelers seeking Tuscany experiences.
Greece is a top destination for Mediterranean cruise lovers.
White-washed villages and unforgettable sunsets.
Beautiful beaches and vibrant nightlife.
A gateway to ancient Greek history.
Spain adds culture, food, and architectural wonders.
A favorite turnaround port with endless sightseeing.
Rich with museums, beaches, and Mediterranean cuisine.
Short but memorable port stops along the Riviera.
A coastal blend of culture and history.
Perfect for glamorous getaways.
Picking the right itinerary depends on your travel style and interests. With so many routes available, these tips help match you with the ideal cruise.
Choose a Western Mediterranean itinerary. It includes:
Italy
France
Spain
This gives you a broad introduction to European culture.
Pick a Greek Islands route. These sailings include stops at Santorini, Mykonos, and Crete.
Eastern Mediterranean or Italy-focused itineraries are perfect, as they include:
Athens
Ephesus
Rome
Florence
Choose a combination itinerary that includes both Eastern and Western Mediterranean ports.
Mediterranean cruises aren’t just about sailing between ports—they’re about fully experiencing European culture and traditions. With so many scenic coastlines, ancient ruins, vibrant cities, and culinary delights, these cruises have something for every traveler.
Each port brings its own identity, from Italian pasta and French pastries to Greek tavernas and Spanish tapas.
The region is filled with bucket-list landmarks such as:
Acropolis
Pompeii
Colosseum
Dubrovnik’s Medieval Walls
Vatican City
Mediterranean landscapes are a blend of mountains, crystal-blue waters, pastel towns, and golden sunsets.
Royal Caribbean’s ships provide:
High-quality dining
Outstanding entertainment
Multiple pools
Innovative activities
Comfortable cabins
These amenities make the journey just as memorable as the destinations.
Recent Guide